Interest in comedy system?
I once tried a game based on a zoo with "realistic, but still cartoon" animals, like the Madagascar series, Back to the Barnyard, and others.
It's hard. It is much harder than a conventional game because to stay in the theme of Funny Cartoon, players really have to suppress their instincts.
In any other game, the idea is to Solve The Problem.
But the whole concept of cartoon humor is that the early attempts to solve the problem MUST fail, in funny ways. The problem can only be solved by complete accident, or unexpected event.
I would be willing to give it a go as a player.