Babylon 5
I'm considering running a game, but would likely make it a freeform versus system-based game. My initial thought is to set it to start in the transition period between Seasons 1 and 2, only instead of Sheridan being appointed Captain, a much different Commanding Officer replaces Sinclair after his surprise appointment as Ambassador on Minbar. The Players could be a character from the show or make their own, exploring how storylines may diverge from the canon based on the different personalities involved.