Mass Effect
One hundred years to the day the Reaper War ended, and Commander Shepard sacrificed her life to stop the Reapers the virtual aliens known as qehoin declared war on the Council. It officially lasted for four years but it really ended the year prior.
In 2292 suddenly the raloi & yahg species were found to be uplifted. Their introduction to the galactic community was attacking any species related to the Citadel. Immediately suspicion fell upon the salarians since they uplifted the krogans and were seen studying the yahg 106 years earlier. The Citadel Council sent a Spectre to investigate.